Obstructive Sleep Apnea Pathophysiology

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Pathophysiology of adult obstructive sleep apnea.

Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive narrowing or collapse of the pharyngeal airway during sleep. The disorder is associated with major comorbidities including excessive daytime sleepiness and increased risk of cardiovascular disease. The underlying pathophysiology is multifactorial and may vary considerably between individuals. Important risk factors i...

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Pathophysiology of pediatric obstructive sleep apnea.

Sleep-disordered breathing is a common and serious cause of metabolic, cardiovascular, and neurocognitive morbidity in children. The spectrum of obstructive sleep-disordered breathing ranges from habitual snoring to partial or complete airway obstruction, termed obstructive sleep apnea (OSA). Breathing patterns due to airway narrowing are highly variable, including obstructive cycling, increase...

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Invited Review HIGHLIGHTED TOPIC Physiology and Pathophysiology of Sleep Apnea Pathogenesis of obstructive sleep apnea

Ryan, Clodagh M., and T. Douglas Bradley. Pathogenesis of obstructive sleep apnea. J Appl Physiol 99: 2440-2450, 2005; doi:10.1152/japplphysiol.00772.2005.— The pathogenesis of obstructive sleep apnea (OSA) has been under investigation for over 25 years, during which a number of factors that contribute to upper airway (UA) collapse during sleep have been identified. Structural/anatomic factors ...

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Pathophysiology of childhood obstructive sleep apnea: current concepts.

The obstructive sleep apnea syndrome (OSAS) is a common and serious condition during childhood. Its pathophysiology remains poorly understood. Although OSAS is related to adenotonsillar hypertrophy in children, adenotonsillar hypertrophy is not likely the sole cause of sleep-disordered breathing in this age group. Rather, large tonsils and adenoids appear to precipitate OSAS in children with un...

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Pathophysiology of sleep apnea.

Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence of an anatomically compromised, collapsible airway, the sleep-induced loss of compensatory tonic input to the upper airway dilator muscle motor neurons leads to collapse of the pharyngeal airway. In turn, the a...

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ژورنال

عنوان ژورنال: Otolaryngology–Head and Neck Surgery

سال: 2012

ISSN: 0194-5998,1097-6817

DOI: 10.1177/0194599812449008a88